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Table 2 M. tuberculosis study: validation results

From: Predicting bacterial resistance from whole-genome sequences using k-mers and stability selection

  

Stability

Mykrobe

 

R / S

sensi.

speci.

sensi.

speci.

ethambutol

194 / 1391

60.3 (6.9)

97.5 (0.8)

71.6 (6.3)

95.8 (1.1)

isoniazid

370 / 1216

89.7 (3.1)

97.5 (0.9)

84.3 (3.7)

98.6 (0.7)

kanamycin

9 / 460

33.3 (30.8)

98.9 (0.9)

33.3 (30.8)

99.6 (0.6)

ofloxacin

9 / 478

55.6 (32.5)

99.6 (0.6)

55.6 (32.5)

100 (0)

rifampicin

303 / 1262

94.1 (2.7)

99 (0.5)

93.7 (2.7)

99 (0.5)

streptomycin

353 / 1227

77.9 (4.3)

99.1 (0.5)

78.8 (4.3)

99.3 (0.5)

  1. R / S: number of resistant and susceptible strains. Stability : sensitivity (sensi.) and specificity (speci.) values obtained with the stability-based final models. Mykrobe: sensitivity and specificity values obtained with the Mykrobe predictor. Figures into brackets correspond to half of the width of the 95% confidence intervals (CI) that shoud be added and substrated to get the upper and lower bounds of the 95% CI