From: 3D Network exploration and visualisation for lifespan data
Gene symbol | NCBI gene ID | Ageing relevance evidence |
---|---|---|
acdh-7, acdh-8 | 181758 173979 | Expression of human homologous gene ACADM decreases over age in skin [45]. |
aco-1 | 181324 | Mutant animals lacking genes aco-1 and ftn-1 show significant reduced lifespan upon iron stress, while N2 and ftn-2 animals show no difference. The results suggest that ftn-1 and aco-1 are transcriptionally regulated by iron and are important for iron homeostasis affecting lifespan upon iron stress conditions in C. elegans [42]. |
alh-4 | 179026 | Gene alh-4 is involved in determination of adult lifespan [46]. |
acs-3 | 178677 | acs-3 mutants exhibited a significantly shorter lifespan on E. coli OP50 (12.8 days), as compared to WT animals (17.9 days) [52]. |
acs-4 | 176005 | RNAi of acs-4 resulted in a 6.1% increase in lifespan compared to wildtype [53]. |
acs-17 | 180859 | Many “dod” genes are responsible for the longevity of daf-2 mutants. The “dod” genes that could previously be identified as life span regulating genes include among others dod-9/acs-17 [54, 55]. |
alh-5 alh-12 sodh-1 sodh-2 | 178680 176056 179627 179628 | Metabolic fingerprint studies with long-lived mutants daf-2 and eat-2 showed strong upregulation of enzymes involved in alcohol fermentation including alh-5, alh-12, sodh-1 and sodh-2 [56]. |
dbl-1 | 179068 | C. elegans mutants with a loss-of-function in dbl-1 showed reduced lifespan [57]. |
ech-6 | 176376 | Metabolism of short-chain organic acids (e.g. gene ech-6) is upregulated in states of impaired IGF-1 signalling in a daf-2 mutant strain with extended lifespan [47]. |
ech-9 | 184065 | The top five overrepresented categories yielded by the comparative expression analysis in three ets-4 deletion strains with increased lifespan include fatty acid metabolic process genes (acdh-2, ech-9, and C48B4.1) [48]. |
enol-1 | 174423 | Compared to wild type strain N2 the RNAi knockdown of gene enol-1 reduced the mean lifespan by 11-14%. Compared to eat-2 knockout strains it reduced the mean lifespan by 15-19% in strain eat-2(ad1116) and by 28% in strain eat-2(ad465) [41]. |
F08F8.7 | 176043 | F08F8.7 was found to be upregulated in long-living mutant daf-2 in comparison to N2 [56]. |
F54C8.1 | 186222 | Concerning branched-chain amino acid metabolism, F54C8.1 was upregulated in the long-lived mutant daf-2 [56] |
F59F4.1 | 181668 | Gene F59F4.1 was linked to Parkinson’s disease by screens involving alpha-synuclein. In alpha-synuclein expressing nematode lines age dependent degeneration of dopaminergic neurons was observed [49]. |
hacd-1 | 178638 | Gene hacd-1 was linked to lifespan effects of germline mutants by transcriptome analysis [50]. |
idhg-2 | 172430 | Energy metabolism seems to be differentially regulated in long-lived mutants compared to N2. Particularly idhg-2 was upregulated in daf-2 mutants [56]. |
mek-1 | 181004 | The lifespan extending effect of intermittent feeding (IF) of 74.9% in wiltype strain N2 is reduced to 21.7% in the mek-1 loss-of-function strain ks54 [58]. |
pfk-1.2 | 179335 | Long-living mutants show upregulation of pfk-1.2 a gene encoding for one of the key enzymes of glycolysis [56]. |
pkc-2 | 181166 | Knockout of gene pkc-2 decreased the mean lifespan significantly by 3–5% at 15°C and compensated for the short-lived phenotype of trpa-1 mutant worms at 20°C. Overexpression of gene pkc-2 increased the mean lifespan significantly by 3–6% at 20°C [43]. |
plc-3 | 174586 | The youthful swimming phenotype of let-23 (gf) mutant was suppressed by RNAi knockdown of plc-3 and itr-1 [59]. |
pyk-1 | 172744 | Compared to wildtype strain N2 the RNAi knockdown of gene pyk-1 reduced the mean lifespan by 19–21%. And compared to eat-2 knockout strain eat-2(ad1116) it reduced the mean lifespan by 19–29% [41]. |
R04A9.7 | 3565956 | The traditional Chinese medicine Gengnianchun (GNC) prolongs the lifespan of C. elegans. Comparison of genome-wide transcriptional profiling of untreated and GNC treated worms at day 22 showed that GNC downregulated the expression of R04A9.7 [60]. |
Gene symbol | NCBI gene ID | Ageing relevance evidence |
rbx-1 | 179358 | RNAi of rbx-1 results terminal stage arrest during embryogenesis[61]. |
sdhd-1 | 174692 | Extension of lifespan in gas-1 (fc21) was observed after sdhc-1 and sdhd-1 knockdown [62]. |
skr-9 skr-14 sma-4 | 178494 178839 175815 | Wnt signaling is highly involved in the aging process of C. elegans with a shifting dynamic. From L4 to D6 Wnt signalling is upregulated and from D6 to D15 it is down-regulated. Eight genes including skr-9, skr-14, and sma-4, which are involved in the Wnt signalling, were significantly up-regulated from L4 to D6 and down-regulated from D6 to D15 [63]. |
sucg-1, sucl-2 | 177555 175252 | The decrease of female reproductive senescence is a hallmark of ageing. The inactivation of sucg-1 or sucl-2 by RNAi extends the reproductive lifespan [64]. |
T02G5.7 | 3565206 | The gene kat-1, a parolog of gene T02G5.7, is included as AF AF_006931 in AgeFactDB [51]. |
tpi-1 | 174844 | RNAi knockdown of gene tpi-1 reduced the the mean lifespan by 8% and the maximum lifespan by 10% [44]. |