Fig. 4

TOR1 AF/LO Networks. a Basic TOR1 AF/LO network containing only LOs involving the gene TOR1 from S. cerevisiae and all other AFs involved directly in these LOs. LO nodes are labelled with the lifespan change value, if available. “n/a” indicates a missing value. The qualitative lifespan effect is also encoded in the LO node and edge colour, according to the colour scheme below. Network size: 26 nodes, 26 edges; Layout calculation: 3dFL algorithm with standard parameters; b Complete TOR1 AF/LO network containing also all indirectly connected AFs and LOs in addition to those from the basic network in part a. The AFs from the basic network are labelled with their name. Network size: 718 nodes, 933 edges; Layout calculation: FMMM algorithm with standard parameters; cTOR1 network from part b augmented by GO process term nodes. AFs without assigned GO process terms were removed. The LOs were not included, but the information about the qualitative changes was retained in a summarised form, encoded in the AF node colours, according to the colour scheme shown below. The size of the GO process term nodes increases proportional to the number of linked genes (number of incoming edges). Network size: 284 nodes, 420 edges; Layout calculation: FMMM algorithm with standard parameters. The two subnetworks at the top left were moved manually after the export as PNG file; Color scheme (a, b): AF - gene, AF - compound, AF - other factor, LO - increased lifespan, LO - decreased lifespan, LO - unchanged lifespan Color scheme (c): AF - linked to LOs with increased lifespan (opaque: only, transparent: ≥80%), AF - linked to LOs with decreased lifespan (opaque: only, transparent: ≥80%), AF - linked to LOs with highly mixed lifespan changes (increased and decreased >20%), GO - process term