Table 2 Examples of potential disease indications for GPCRs and endogenous peptides and corresponding Open Targets overall scores that represent new target hypotheses or potential repurposing opportunities
From: Uncovering new disease indications for G-protein coupled receptors and their endogenous ligands
| Â | Gene | Disease term | Score | |
|---|---|---|---|---|
GPCRs | Repurposing opportunity | GPR35 | Inflammatory bowel disease | 1.00 |
CXCR4 | Infectious disease | 1.00 | ||
PTGER4 | Inflammatory bowel disease | 0.90 | ||
TSHR | Graves disease | 0.67 | ||
New target | NPSR1 | Asthma | 1.00 | |
LPAR6 | Alopecia | 1.00 | ||
CELSR2 | Coronary heart disease | 0.92 | ||
GPR65 | Crohn’s disease | 0.81 | ||
Endogenous peptide | Repurposing opportunity | TNFSF15 | Inflammatory bowel disease | 1.00 |
AGT | Hypertension | 1.00 | ||
IL17F | Immune system disease | 1.00 | ||
CALCA | Cardiovascular disease | 1.00 | ||
New target | FBN1 | Vascular disease | 1.00 | |
COL3A1 | Cardiovascular disease | 1.00 | ||
NPPA | Cardiomyopathy | 1.00 | ||
IL33 | Respiratory system disease | 0.77 | ||