Fig. 1

Distribution of the overall Open Targets score and relationship to individual data types. a Empirical density and cumulative distribution of the Open Targets score. Density and distribution functions were estimated using the R functions density() and ecdf(), respectively, with default parameters and using all pairs and 10,000 randomly selected pairs, respectively. b Number of gene-disease pairs with positive scores by type of score (overall, genetic association, somatic mutation, known drugs, RNA expression, affected pathways, animal models, and literature mining). c Comparison of the overall score of a disease-gene association and the number of data sources where the individual data type score is > 0. The top panel shows the counts of target-disease pairs corresponding to the scores below