Fig. 6
From: PRS-on-Spark (PRSoS): a novel, efficient and flexible approach for generating polygenic risk scores
Best-fit PRS model selection. Bar plots show the proportion of variance in depressive symptoms explained by PRS for major depressive disorder (MDD) as a function of dataset with and without strand-ambiguous SNPs. Only the best-fit models are shown (PT: Imputed PP = 0.1, Imputed HC = 0.1, Array Data = 0.2). Numbers in boxed inserts refer to the number of SNPs included in each PRS. Imputed PP = imputed posterior probabilities, Imputed HC = imputed posterior probabilities converted to “hard calls”, Array Data = observed genotypes