Fig. 2

Distribution of topology and protein in groups of “Non-Prevalent” (left to dashed line) and “Prevalent” (right to dashed lines) has been shown as violin plots. This plot is generated for the statistically significant topologies (P-value < 0.001; Additional file 1: Table S3), from represented dataset of PDB (58,186 protein chains). Description of dataset has been provided in the text and supplementary. The shape of violin plot describes the kernel density estimation of the distribution of data in different topologies and proteins. A summary of statistics can be drawn from the inner boxplot. The white dot represents the median, thick bar shows the interquartile range and thin line describes the 95% confidence interval. A clear distinction can be drawn on the nature of distribution of proteins as well as topologies in “Prevalent” and “Non-prevalent” groups. A comparison of distribution with non-parametric Wilcoxon rank-sum test has been performed and P-values are indicated as ‘*’ (‘****’: P-val < 0.001 and ‘**’: P-val < 0.01) in the bottom