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Table 1 Model parameters

From: Computer simulations of the signalling network in FLT3 +-acute myeloid leukaemia – indications for an optimal dosage of inhibitors against FLT3 and CDK6

Parameter Name

Description

β

Basal level of a node’s activity

δ

Decay constant of a node

γ

Interaction strength between two nodes

 

(affinity)

η

Nonlinearity in signalling interaction

 

(Hill coefficient)

α

Multiplicative scaling factor applied to the

 

regulatory function

  1. Parameters used to define model’s nodes and links