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Table 1 Key performance comparison of ‘SpirPep’ to other bioactive peptide identification tools

From: SpirPep: an in silico digestion-based platform to assist bioactive peptides discovery from a genome-wide database

Category

Bioactive peptide identification tool

Input

In silico peptide digestion

Bioactive peptide prediction

Result of in silico peptide digestion/bioactive peptide prediction tool

Accessibility

Bioactivity

No. of known bioactive peptide sequence

No. of protein per analysis

No. of Enzyme selection

No. of Miscleavage

Yes/No

Identification

Original protein track back

Resulting peptide categorized by enzyme

Protein-peptide alignment visualization by GBrowse

In silico peptide digestion tool

PeptideCutter tool

1 protein

1–29

N/A

No

N/A

N/A

N/A

√

N/A

http://web.expasy.org/peptide_cutter/

Bioactive peptide prediction tool

PeptideLocator

1 Uniprot ID (≤10,000 aa)

N/A

N/A

Yes

N/A

Unknown

N/A

N/A

N/A

http://bioware.ucd.ie/~compass/biowareweb/Server_pages/biopred.php

PeptideRanker

Up to 150 peptides

N/A

N/A

Yes

N/A

Unknown

N/A

N/A

N/A

http://bioware.ucd.ie/~compass/biowareweb/Server_pages/peptideranker.php

In silico peptide digestion and bioactive peptide prediction tool

mMass

1 protein

1

As user input

Yes

√

612 sequences

N/A

N/A

N/A

Standalone version (http://www.mmass.org/download/)

BIOPEP

1 protein

1–3

N/A

Yes

√

3587 sequences

N/A

N/A

N/A

http://www.uwm.edu.pl/biochemia/index.php/en/biopep

SpirPep (In this study)

Thousands proteins or the whole genome

1–15

0–3

Yes

√

28,892 sequences

√

√

√

http://spirpepapp.sbi.kmutt.ac.th/SpirPep/SpirPepTool

  1. √ = Available; N/A = Not available