Table 1 Distribution of Samples in Published PheWAS. In this table, we highlight the range of cases and controls for PheWAS on binary phenotypes and range of sample sizes for the quantitative phenotypes used in few PheWAS analyses in literature
From: A simulation study investigating power estimates in phenome-wide association studies
Study | Min/Max Case Counts Range | Min/Max Control Count Range |
|---|---|---|
Binary Phenotypes (EHR-based ICD-9 codes) | ||
Denny et al. [23] | 25/8185 | 4206/13746 |
Hebbring et al. [9] | 11/3450 | NA |
Namjou et al. [24] | 23/1131 | 1840/3609 |
Simonti et al. [25] | 20/8128 | 794/13258 |
Shameer et al. [26] | 22/6082 | NA |
Karnes et al. [11] | 40/12197 | 9354/28737 |
Quantitative Phenotypes | ||
Study | Sample Size Range | |
Karaca et al. [27] | 323–973 | |
Hall et al. [14] | 258–6363 | |
Moore and Verma et al. [16] | 1175–3269 | |
Pendergrass et al. [13] | 48–1331 | |