Fig. 2
From: ATMAD: robust image analysis for Automatic Tissue MicroArray De-arraying
Overview of our TMA de-arraying approach. The proposed ATMAD approach consists in two steps : (i) tissue core localization; (ii) estimation of array coordinates of tissue cores. The localization step is performed by combining a fast wavelet-based detection and an ellipse-shaped active contour to produce accurate core positions for the second step. The second step is dedicated to the estimation of the deformation of the TMA grid. The objective is to refine the de-arraying result by providing additionally potential positions of tissue cores which were not recognized at the first step. The de-arraying result is presented as a regular array to facilitate the seeking of row and column coordinates of each core