Fig. 14

Example of de-arraying on a fluorescence TMA image with the activation of both the segmentation and of the non-linear estimation for the TMA grid deformation. a Contrast-enhanced original image. b Detection map (accurate detection is marked in white, wrong detection is marked in red). c Segmentation of TMA cores (recognized cores are colored by blue ellipses). d Estimated TMA grid (potential core position is marked by a red cross). e Recognized TMA cores (cores which are additionally recognized are colored by orange ellipses). f Final de-arraying result in array format (recognized core position is marked by green box). g Manual annotations for comparison