From: Simulating autosomal genotypes with realistic linkage disequilibrium and a spiked-in genetic effect
Simulation Setup | Simulation Results | ||||||
---|---|---|---|---|---|---|---|
Scenario | Allele Frequency for each of the 4 SNPs in each pathway | True Relative Risk | Average Estimated Relative Risk (95% CI for the mean) | Estimated Coverage of Nominal 95% CIs | |||
 |  | Pathway 1 | Pathway 2 | Pathway 1 | Pathway 2 | Pathway 1 | Pathway 2 |
Stratified null | a | 1 | 1 | 1.00 (0.99,1.01) | 1.00 (0.99,1.01) | 0.948 | 0.952 |
Alternative b | 0.3 | 1.65 | 2.71 | 1.65 (1.63,1.66) | 2.73 (2.71,2.75) | 0.948 | 0.959 |
Alternative b | 0.2 | 1.65 | 2.71 | 1.64 (1.61,1.67) | 2.72 (2.67,2.77) | 0.963 | 0.964 |