Fig. 2From: ClusterTAD: an unsupervised machine learning approach to detecting topologically associated domains of chromosomes from Hi-C dataIllustration of the topologically associated domains. a Illustration of the basic elements related to TAD: domain, border, boundary, and gap. A domain is a TAD. A boundary is the chromosomal region between two consecutive TADs. The border marks the start/end of a domain. A gap is a point with no interaction in the contact matrix. b The calculation of TAD quality score. Two adjacent TADs are denoted as i and j. The area between TADs i and j that has few interactions is labeled as E. The intra(i) is the average contact frequency within a TAD (e.g. the area marked i). The inter(i, j) is the average contact frequency of the area marked as E. The difference of the two is the quality of TAD iBack to article page