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Fig. 1 | BMC Bioinformatics

Fig. 1

From: BoolFilter: an R package for estimation and identification of partially-observed Boolean dynamical systems

Fig. 1

The p53-MDM2 Boolean gene regulatory network. The state of the system at time k is represented by a vector (ATM k ,p53 k ,WIP1 k ,MDM2 k ), where the subscript k indicates expression state at time k. The Boolean input u k =dna_dsb k at time k indicates the presence of DNA double strand breaks. Counter-clockwise from the top right: the activation/inhibition pathway diagram, transition diagrams corresponding to a constant inputs dna_dsb k ≡0 (no stress) and dna_dsb k ≡1 (DNA damage), and Boolean equations that describe the state transitions

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BMC Bioinformatics

ISSN: 1471-2105

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