Fig. 3
From: A rapid and accurate approach for prediction of interactomes from co-elution data (PrInCE)
Predicting interactions (Interactions.m). a. Reference database. Subset of the CORUM reference database, including ribosomal and proteasomal proteins, expressed as a square pairwise matrix. Intra-complex interactions (white) are pairs of proteins from the same reference complex, inter-complex interactions (black) are pairs of proteins contained in the reference that are not co-complex members, and unknown/novel pairs (grey) have one or more protein not contained in the reference. Proteins are sorted according to their peak location. b. Interaction probability for each pair of proteins using the labels in (a) and distance measures. c. Square pairwise matrix of predicted interactions at two precision levels, 50% (0.50) and 75% (0.75). Interactions are predicted by applying a constant threshold to interaction score. d. Precision versus accumulated number of interactions. e. Overlap between three gold standard references (CORUM, IntAct, and hu.MAP). f. Predicted interactions using gold standard references from (e). 5527 interactions were commonly predicted from all three gold standards (intersection)