From: Block-based characterization of protease specificity from substrate sequence profile
Protease | P2 | P1 | Block B2 |
---|---|---|---|
(a) The top prominent B2 blocks of proteases listed in Fig. 6a | |||
Caspase 3 | Val | Asp | ValAsp |
Kexin | Lys | Arg | LysArg |
Furin | Lys, Arg | Arg | LysArg, ArgArg |
PCSK6 peptidase | Lys, Arg | Arg | LysArg, ArgArg |
(b) The top prominent B2 blocks of proteases listed in Fig. 6b | |||
HIV-1 Retropepsin | Val, Glu, Ile | Leu, Phe,Tyr | GluLeu, ValLeu |
MMP2 | Ala, Ser, Gly | Ala, Gly, Asn | AlaAla, SerGly |
MMP9 | Ala, Gly, Pro | Gly, Ala, Pro | ProGly, AlaAla |