Fig. 7

The topology alterations of the network biomarker. a The background network is the biomarker of “The regulation of insulin secretion”, which is a union network of (b) normal-specific active sub-network and (c) disease-specific active sub-network identified by CNS. Nodes and edges in black present genes and interactions are selected under a certain state; Nodes and edges in gray mean genes and interactions are background features and not selected