Fig. 4

Schematic representation of the residues classification according the hydrophobicity (blue as hydrophilic and red as hydrophobic). The first residue of the peptide is K and it is hydrophilic, the next residue is L and it is hydrophobic, in consequence K is a class 2 residue (C2). The second residue is L and the next residue is hydrophobic too, then L is a class 1 residue (C1). The last residue must be coupled with the previous residue in both directions, in this case D and T are hydrophilic then they are class 1 residues (C1)