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Fig. 6 | BMC Bioinformatics

Fig. 6

From: ImiRP: a computational approach to microRNA target site mutation

Fig. 6

ImiRP output user interface. Input mutation sites spaced less than seven nucleotides apart are grouped into independent regions and each region is mutated independently of other regions. The output user interface displays up to five mutant sequences for each region that satisfy the specified mutation parameters. For example, the output mutations for ImiRP Test (Fig. 2) will not have generated any new 8mer, 7mer-m8, or 7mer-A1 predicted miRNA target sites. The original input sequence for each region is displayed above the mutants for comparison, and brackets denote the bounds of each specified mutation site. The user must select one desired mutant for each region, and the changes are displayed as an assembled mutant sequence. Once the selection process is complete, the user may download a folder containing information about their assembled mutant sequence, and predicted miRNA target sites in the input and mutant sequences

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