Fig. 3

Application of pcaReduce to single cell RNA sequencing of 11 cell lines. a Projection of the data on to the first two principal components. b Performance of pcaReduce, the horizontal axis corresponds to a level in the hierarchical cluster structure reported by pcaReduce, the vertical axis show the Adjusted Rand Index (ARANDI) score between the tissue-level (green) and cell-line level labels (in blue) and the clustering reported by each level of the hierarchical clustering of pcaReduce. Each line correspond to a single run of pcaReduce using probabilistic sampling. c The most probable cellular hierarchy identified using pcaReduce