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Fig. 3 | BMC Bioinformatics

Fig. 3

From: Modeling the integration of bacterial rRNA fragments into the human cancer genome

Fig. 3

A bacterial DNA integration into the KPL-1 cell line genome was modeled using the JSD and AD calculations. Based on the data from the Cancer Cell Line Encyclopedia [16] and a similar data set from Genentech [17], the JSD and AD methods predicted that the bacterial & human consensus sequences are 0 bp apart (a, b). However, PCR amplification and sequencing revealed an additional 2 bp of sequence between the two consensus sequences as illustrated (c). Consistent with this, a plot of the sequence coverage of the reads across the junction is relatively constant (c). No further insertions or deletions are observed in the underlying reads (data not shown)

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