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Table 3 The p-value represents the results of a one-sided binomial hypothesis test where H 0:p 0=p 1 and H a :p 0>p 1 where p 0 is the proportion of structures found that had a corresponding entry in OMIM when using the quaternary version of the method and p 1 is the proportion of structures with a corresponding entry in OMIM when using the tertiary version of the method

From: Leveraging protein quaternary structure to identify oncogenic driver mutations

 

Quaternary only

Tertiary only

p-value

Method

Num structures

Num in OMIM

Num structures

Num in OMIM

 

iPAC

56

42 (75 %)

33

8 (24 %)

4.49×10−6

GraphPAC

43

31 (72 %)

27

10 (37 %)

4.04×10−3

SpacePAC

21

11 (52 %)

15

5 (33 %)

0.214