Regularized logistic regression with network-based pairwise interaction for biomarker identification in breast cancer

Table 5 The Gene Ontology results of the subnetwork identified by RLRNPI-AEN for dataset GSE11121

Subnetwork	GO number	Ontology description	Adjusted p-value
AGER ATP2A3 CRK CSF2RA DLGAP2 ECT2 F2RL2 FYN GRB2 MAP2K5 NCK1 PIK3R1 SEMA7A TPSAB1 TPSB2 WIPF2	GO:0002433	immune response-regulating cell surface receptor signaling pathway involved in phagocytosis	2.66×10⁻¹⁰
	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	2.66×10⁻¹⁰
	GO:0038094	Fc-gamma receptor signaling pathway	2.66×10⁻¹⁰
	GO:0002431	Fc receptor mediated stimulatory signaling pathway	2.70×10⁻¹⁰
	GO:0006909	phagocytosis	5.53×10⁻⁸
CREB3 MS4A1 ICAM4 FA2H	GO:0031726	CCR1 chemokine receptor binding	2.25×10⁻²
	GO:0008140	cAMP response element binding protein binding	2.25×10⁻²
	GO:0044877	macromolecular complex binding	2.25×10⁻²
	GO:0035497	cAMP response element binding	2.76×10⁻²
	GO:0005102	receptor binding	2.76×10⁻²
AGGF1 CCDC85B PRC1 NGFRAP1	GO:0005123	death receptor binding	4.17×10⁻²
	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	4.17×10⁻²
	GO:0016505	peptidase activator activity involved in apoptotic process	4.17×10⁻²
	GO:0019894	kinesin binding	4.17×10⁻²
	GO:0016504	peptidase activator activity	4.17×10⁻²

The first column (Subnetwork) presents the elements of subnetwork of which the functional and biological relationship are analyzed based on the GO annotation

ISSN: 1471-2105