Fig. 1From: Intra- and interspecies gene expression models for predicting drug response in canine osteosarcomaThe Co-expression Extrapolation (COXEN) method. Steps 1–3 involve identifying a gene signature that predicts chemosensitivity from the reference set. Steps 4–5 involve gene expression data from the co-expression set and identifying a subset of the gene signature that shares strong co-expression with the co-expression set. The resulting genes are candidates in prediction model development in step 6, and the resulting predictions are compared to actual chemosensitivity or clinical outcome in step 7Back to article page