Table 1 Functional annotation analysis using DAVID (http://david.abcc.ncifcrf.gov/) for 4 lists of differentially expressed genes (DEGs)
Term | P value | Benjamini | |
|---|---|---|---|
Enriched pathways for the 665 differentially expressed genes in mCRPC samples (without TIN correction). | ribosomal protein | 7.50E-19 | 3.10E-16 |
ribosome | 1.10E-17 | 4.10E-15 | |
structural constituent of ribosome | 2.00E-17 | 1.10E-14 | |
ribosomal subunit | 3.70E-16 | 6.30E-14 | |
cytosolic ribosome | 1.00E-14 | 1.30E-12 | |
translational elongation | 9.70E-13 | 1.80E-09 | |
large ribosomal subunit | 5.40E-12 | 5.10E-10 | |
ribonucleoprotein complex | 1.20E-11 | 9.40E-10 | |
translation | 7.70E-10 | 7.10E-07 | |
cytosolic large ribosomal subunit | 7.10E-09 | 3.80E-07 | |
Enriched pathways for the top 500 differentially expressed genes in human brain Glioblastoma cell line data (without TIN correction). | ribonucleoprotein | 9.00E-44 | 1.70E-41 |
structural constituent of ribosome | 3.70E-37 | 1.90E-34 | |
ribosome | 1.80E-34 | 7.40E-32 | |
ribonucleoprotein complex | 1.20E-32 | 2.60E-30 | |
ribosomal subunit | 8.80E-30 | 1.20E-27 | |
translational elongation | 2.80E-28 | 4.40E-25 | |
translation | 3.70E-26 | 2.90E-23 | |
cytosolic ribosome | 1.10E-21 | 9.60E-20 | |
structural molecule activity | 2.70E-20 | 6.80E-18 | |
large ribosomal subunit | 4.60E-20 | 2.80E-18 | |
Enriched pathways for the 289 differentially expressed genes in mCRPC samples (after TIN correction). | icosanoid metabolic process | 3.10E-05 | 3.60E-02 |
unsaturated fatty acid metabolic process | 4.90E-05 | 2.90E-02 | |
fatty acid metabolic process | 5.60E-05 | 2.20E-02 | |
prostaglandin metabolic process | 9.20E-05 | 2.70E-02 | |
prostanoid metabolic process | 9.20E-05 | 2.70E-02 | |
Arachidonic acid metabolism | 7.80E-04 | 7.50E-02 | |
PPAR signaling pathway | 2.00E-03 | 9.60E-02 | |
Enriched pathways for the 117 differentially expressed genes in mCRPC samples (using 3′ tag counting method). | protein homooligomerization | 2.20E-03 | 6.00E-01 |
protein complex assembly | 8.50E-03 | 8.30E-01 | |
protein complex biogenesis | 8.50E-03 | 8.30E-01 | |
macromolecular complex assembly | 1.40E-02 | 9.10E-01 | |
protein oligomerization | 1.80E-02 | 9.20E-01 | |
macromolecular complex subunit organization | 2.10E-02 | 9.20E-01 | |
cellular macromolecular complex subunit organization | 3.40E-01 | 1.00E + 00 |