Skip to main content

Table 2 Similar to Table 1, but this comparison is based on the second set of simulation studies (with subject effect)

From: A full Bayesian partition model for identifying hypo- and hyper-methylated loci from single nucleotide resolution sequencing data

  

Logistic

DSS

z-test

Bayesian

  

regression

   

γ=0.01

FDR

0.0027

0

0.0034

0.0069

 

mdFDR

0.0029

0

0.0036

0.008

 

TPR

0.1953

0.0171

0.183

0.2494

 

TPR_hypo

0.1948

0.0167

0.1918

0.2545

 

TPR_hyper

0.1958

0.0176

0.171

0.2418

γ=0.05

FDR

0.0097

0

0.0113

0.014

 

mdFDR

0.0097

0

0.0113

0.0141

 

TPR

0.3554

0.0364

0.3235

0.4038

 

TPR_hypo

0.3604

0.0375

0.3392

0.419

 

TPR_hyper

0.3494

0.035

0.3044

0.3853

γ=0.1

FDR

0.0119

0

0.0142

0.0156

 

mdFDR

0.0119

0

0.0142

0.0156

 

TPR

0.5053

0.0668

0.4588

0.5745

 

TPR_hypo

0.5021

0.0692

0.4637

0.5836

 

TPR_hyper

0.509

0.0641

0.453

0.5637

γ=0.15

FDR

0.012

0

0.0147

0.0156

 

mdFDR

0.012

0

0.0147

0.0156

 

TPR

0.6385

0.1074

0.5939

0.7158

 

TPR_hypo

0.6309

0.112

0.5905

0.7205

 

TPR_hyper

0.6477

0.1016

0.5981

0.7101

γ=0.2

FDR

0.0116

0.0001

0.0146

0.0153

 

mdFDR

0.0116

0.0001

0.0146

0.0153

 

TPR

0.7546

0.1576

0.7203

0.8254

 

TPR_hypo

0.7459

0.1612

0.7129

0.8287

 

TPR_hyper

0.7659

0.1529

0.7298

0.821