Table 1 Amino acid composition of substitution matrices and the Swiss-Prot database (%)
Amino acid | GPCRtm | JTTtm [44] | PHDhtm [22] | BLOSUM62 [20] | Swiss-Prot [45] |
|---|---|---|---|---|---|
Ala (A) | 8.0 | 10.5 | 8.8 | 7.4 | 8.3 |
Cys (C) | 3.6 | 2.2 | 2.6 | 2.5 | 1.4 |
Asp (D) | 2.1 | 0.9 | 1.4 | 5.4 | 5.5 |
Glu (E) | 1.9 | 1.0 | 1.0 | 5.4 | 6.7 |
Phe (F) | 7.3 | 7.7 | 9.3 | 4.7 | 3.9 |
Gly (G) | 4.6 | 7.6 | 5.7 | 7.4 | 7.0 |
His (H) | 2.1 | 1.7 | 1.1 | 2.6 | 2.3 |
Ile (I) | 8.1 | 11.9 | 11.0 | 6.8 | 5.9 |
Lys (K) | 3.4 | 1.1 | 0.9 | 5.8 | 5.8 |
Leu (L) | 14.1 | 16.3 | 16.0 | 9.9 | 9.7 |
Met (M) | 3.1 | 3.3 | 4.1 | 2.8 | 2.4 |
Asn (N) | 3.4 | 1.8 | 2.2 | 4.5 | 4.1 |
Pro (P) | 3.8 | 2.6 | 3.2 | 3.9 | 4.7 |
Gln (Q) | 2.2 | 1.4 | 1.2 | 3.4 | 3.9 |
Arg (R) | 4.5 | 1.6 | 2.1 | 5.2 | 5.5 |
Ser (S) | 6.8 | 5.7 | 6.5 | 5.7 | 6.6 |
Thr (T) | 5.6 | 5.2 | 5.3 | 5.1 | 5.3 |
Val (V) | 9.2 | 11.9 | 11.0 | 7.3 | 6.9 |
Trp (W) | 1.9 | 2.2 | 1.9 | 1.3 | 1.1 |
Tyr (Y) | 4.3 | 3.2 | 4.7 | 3.2 | 2.9 |