Skip to main content
Fig. 4 | BMC Bioinformatics

Fig. 4

From: GPCRtm: An amino acid substitution matrix for the transmembrane region of class A G Protein-Coupled Receptors

Fig. 4

Diversity of ligand binding interactions involved polar and charge residues in the TM region of the rhodopsin family of GPCRs. The crystal structures corresponding to: a Rhodopsin (PDBid: 1U19), b Histamine H1R (3RZE), c Muscarinic M3R (4DAJ), d Opioid κ-OR (4DJH), e Chemokine CCR5 (4MBS), f Purinergic P2Y12R (4NTJ), g Adenosine A2AR (2YDV) and h Adrenergic β2AR (4LDO). Polar and charged residues of the receptors at 4 Å distance of ligands (in vdW spheres) are displayed as sticks and named in the corresponding helices (circular labels). The color code of the helices is: TM1 (light grey), TM2 (yellow), TM3 (red), TM4 (grey), TM5 (green), TM6 (darkblue) and TM7 (cyan). All structures are oriented with the TM4 perpendicular to the plane

Back to article page

BMC Bioinformatics

ISSN: 1471-2105

Contact us