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Figure 5 | BMC Bioinformatics

Figure 5

From: A network model for angiogenesis in ovarian cancer

Figure 5

Proposed therapeutic approaches. (A) A summary of the results found by comparing the expression patterns of genes in “treatment” versus “control” samples in each of the GEO datasets to “classes” of genes defined in our network analysis. We report the significance of association of differential expression with the indicated gene class, using a GSEA approach [110]; colors indicate direction of differential expression (red - increase upon treatment, blue - decrease upon treatment). (B) An illustration of some of the key findings regarding the potential mechanisms driving angiogenesis in ovarian cancer found using PANDA, as well as three potential treatments that may inhibit angiogenesis.

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