Figure 4

Enrichment of interactions within and between protein complexes. (A) Schematic illustration of interactions that appear between and within complexes. In (B) we determined the number of interactions between MDSet, essential or e-MDSet proteins in the same complex as well as within complexes in E. coli, S. cerevisiae and H. sapiens. As a random null model, we resampled proteins in complexes 10,000 times. Generally, we found that interactions between complexes appear diluted while interactions in the same complexes seemed to be enriched. While they appeared significant in sets of interactions between essential proteins we observed that such signals were enhanced in interaction sets between e-MDSet proteins (P < 10⁻⁴).