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Table 2 Cross-validation performance of the structure-based SVM method as a function of different protein environments centred on the C-α of the mutated residue

From: A three-state prediction of single point mutations on protein stability changes

Method

Radius(A)

<Q>

<C>

Q[-]

P[-]

C[-]

Q[N]

P[N]

C[N]

Q[+]

P[+]

C[+]

SVM-BASE

0

0.49

0.21

0.54

0.44

0.29

0.44

0.58

0.13

0.54

0.44

0.29

SVM-3D6

6

0.59

0.34

0.52

0.52

0.36

0.66

0.67

0.33

0.52

0.52

0.36

SVM-3D9

9

0.61

0.35

0.50

0.57

0.39

0.72

0.64

0.32

0.50

0.57

0.39

SVM-3D12

12

0.59

0.33

0.48

0.53

0.35

0.70

0.64

0.31

0.48

0.53

0.36

  1. For notation see Table 1.