Figure 1From: A three-state prediction of single point mutations on protein stability changesFree Energy distribution of the database. Distribution of ΔΔG (kcal/mole) values on the 1623 mutations as extracted from the ProTherm database. The grey histograms (left side) indicates the destabilizing mutations in the database. The dotted bars (right side) are the occurrences of stabilizing mutations. The black histograms are considered the neutral mutation and their absolute ΔΔG value is lower than 1.0 kcal/mole.Back to article page