Aggregation methods for clustering. A) Schematic comparison between complete- and single-linkage method properties. Two domains (X and Y) with their respective binding regions (A to G) are schematized. Dendrograms obtained from the clustering of PBRs using complete- and single-linkage methods are shown at the right of each domain scheme for comparison. B) Clustering of the PBRs of the PTB domain. The dendrograms derived from the clustering using complete- and average-linkage are shown in the left and right panels, respectively. An example to illustrate the range of similarity that could be used to produce a specific cutting point is represented by the thickness of a yellow line for both methods. The centre of the figure contains the graphical representation of the PTB binding regions obtained using the complete-linkage at zero Si cut-off. The PTB domain is represented as a grey surface, and the corresponding binding partners in coloured ribbons. Two graphs representing the number of clusters at different Si cut-offs are shown at the bottom.