PEPOP cluster | PEPOP segment | Position ([PDB: 1SFG] chain A) | mAb1 | |||||
---|---|---|---|---|---|---|---|---|
D1.3 | D11.15 | D44.1 | HyHEL-5 | HyHEL-10 | HyHEL-63 | |||
Cluster1 | Segment17 | 93–94 | 1/10 (103) | 7/16 (93, 96, 97, 100, 101, 102, 103) | 7/23 (93, 96, 97, 100, 101, 102, 103) | |||
Segment18 | 96–97 | |||||||
Segment19 | 100–103 | |||||||
Cluster2 | Segment2 | 10–16 | 10/10 (13, 14, 19, 21, 22, 24, 117, 119, 121, 125) | 9/10 (21, 23, 106, 112, 113, 116, 117, 118, 119) | 5/16 (15, 16, 19, 20, 21) | 8/23 (13, 14, 15, 16, 18, 19, 20, 21) | ||
Segment20 | 106–109 | |||||||
Segment21 | 111–114 | |||||||
Segment22 | 116–119 | |||||||
Segment23 | 121–129 | |||||||
Segment3 | 18–24 | |||||||
Segment4 | 27–28 | |||||||
Cluster3 | Segment10 | 56–57 | 11/11 (41, 45, 46, 47, 49, 53, 67, 68, 70, 81, 84) | 13/14 (41, 43, 44, 45, 46, 47, (63, 73, 75, 48, 49, 89) 53, 67, 68, 70, 84) | 4/16(63, 73, 75, 89) | 6/23 (62, 63, 73, 75, 77, 89) | ||
Segment11 | 59 | |||||||
Segment12 | 61–63 | |||||||
Segment13 | 65–68 | |||||||
Segment14 | 70–79 | |||||||
Segment15 | 81–82 | |||||||
Segment16 | 84–90 | |||||||
Segment8 | 41–49 | |||||||
Segment9 | 53 | |||||||
Cluster4 | Segment1 | 1–8 | ||||||
Segment5 | 33–35 | |||||||
Segment6 | 37 | |||||||
Segment7 | 39 | |||||||
amino acids not accessible | 1/14 (69) | 2/23 (98, 99) |