Meta-analysis of breast cancer microarray studies in conjunction with conserved cis-elements suggest patterns for coordinate regulation

Table 6 Top Scoring 6-mer and 7-mer miRNA seeds identified in normalized 3'UTRs. Top 1% and 5% Gene Sets.

Rank	Seed	Fisher's exact p-value	Hochberg adj p-value	ER+ Randomiz. test p-val	ER- Randomiz. test p-val	Seed	Fisher's exact p-value	Hochberg adj p-value	ER+ Randomiz. test p-val	ER- Randomiz. test p-val
Top 1% 6-mer						Top 1% 7-mer
1	ATCTGG	0.0002	0.0547	0.000	0.018	CACTGCC	0.0011	0.4099	0.008	0.003
2	GGTACT	0.0005	0.1811	0.018	0.001	ACTATTA	0.0012	0.4328	0.000	0.019
3	AGCACA	0.0015	0.5048	0.005	0.004	TCTAGAG	0.0079	1.0000	0.021	0.006
4	CACTTT	0.0017	0.5921	0.001	0.029	ATTACAT	0.0113	1.0000	0.012	0.042
5	ACTGCC	0.0019	0.6339	0.004	0.028	GTCAACC	0.0146	1.0000	0.028	0.007
6	CTATTA	0.0025	0.8495	0.007	0.025	TGTATTA	0.0175	1.0000	0.052	0.022
7	AGTTTT	0.0035	1.0000	0.086	0.006	TGGTACT	0.0214	1.0000	0.007	0.117
8	GACACA	0.0059	1.0000	0.076	0.006	AAAGGGA	0.0228	1.0000	0.294	0.000
9	AGTCCA	0.0070	1.0000	0.027	0.006	AAGCACA	0.0273	1.0000	0.012	0.049
10	AGAGTT	0.0076	1.0000	0.218	0.001	GTGTTGA	0.0279	1.0000	0.462	0.000
Top 5% 6-mer						Top 5% 7-mer
1	ATTATA	0.0000	0.0004	0.000	0.004	TGCCTTA	0.0000	0.0056	0.000	0.000
2	GCCTTA	0.0000	0.0031	0.000	0.002	ATATGCA	0.0000	0.0126	0.000	0.001
3	TGTTAA	0.0000	0.0038	0.000	0.000	TAATAAT	0.0003	0.1053	0.002	0.000
4	TTATAT	0.0000	0.0040	0.000	0.039	GATTTTT	0.0004	0.1569	0.000	0.008
5	TGAAGG	0.0000	0.0052	0.000	0.021	GTTATAT	0.0006	0.2226	0.000	0.004
6	TAAGCT	0.0000	0.0064	0.000	0.000	CCAACTC	0.0010	0.3524	0.015	0.000
7	ACTTCA	0.0000	0.0095	0.000	0.000	AATGCAT	0.0013	0.4888	0.000	0.008
8	ATTTCA	0.0000	0.0141	0.000	0.008	TCTGATA	0.0014	0.5104	0.140	0.000
9	CATTTG	0.0000	0.0150	0.000	0.014	ATTACAT	0.0014	0.5142	0.001	0.002
10	AGTATT	0.0001	0.0197	0.000	0.062	TCTGATC	0.0014	0.5186	0.000	0.107

ISSN: 1471-2105