Figure 2
From: Natural computation meta-heuristics for the in silico optimization of microbial strains
Comparison of the EA and SA algorithms. A scheme illustrating the major steps of the EA and SA algorithms developed in this work. Each individual represents a set of genes/reactions to be deleted from the model. The task is to find one or more individuals that are predicted to have high yield or productivity (in general, any flux phenotype). The prediction of the flux phenotype is based on optimality principles of metabolic networks such as Flux Balance Analysis.