Figure 4

Mapping functional residues to HMM states. Each column in the globin alignment maps to either match or insert state, including the columns that represent functional sites. The columns labeled by As represents active site positions, whereas Bs columns represents binding site positions. M _i , I _i and D _i represent match, insert and delete states in HMM architecture, respectively. In this illustration, As1 mapped to M₈ state, and the Bs₁, Bs₂ and Bs₃ columns mapped to M₂, M₁₃ and I₁₅ states, respectively.