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Figure 3 | BMC Bioinformatics

Figure 3

From: Prediction of specificity-determining residues for small-molecule kinase inhibitors

Figure 3

S-Filter results for SB-203580. S-Filter is available through the PFAAT application. Percent inhibition values are displayed to the right of the kinase name. S-Filter analysis was restricted to alignment columns that correspond to residues that make contact with SB-203580. All residues that do not make contact with SB-203580 are hidden so that all contact resides appear as a contiguous sequence. S-Filter has applied filters to the tenth and eleventh columns as indicated by the filter boxes above the respective columns. Leucine and threonine are predicted as selectivity determinants, and all uninhibited kinases that do not have these residues are hidden by the respective filters.

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