Table 2 Selected features

is_HLA

Whether the protein containing the SAP belongs to HLA family [18].

nor_diff_freq

Normalized difference between mutant-type residue frequency and wild-type residue frequency.

DAYM780301

Log odds matrix for 250 PAMs [27]. The value between two amino acids shows how often one amino acid replaces another one in evolution.

FEND850101

Structure-Genetic matrix [28]. This matrix takes into account of the structural similarities of amino acids and the genetic code.

ZHAC000105

Environment-dependent residue contact energies [29]. The residue contact energies in different structural environment.

HENS920103

BLOSUM80 substitution matrix [30]. The value between two amino acids is defined based on the log likelihood of one amino acid substitutes the other by chance in sequence alignment.

NAKH900106

Normalized composition from animal [31]. Normalized residue composition calculated from animal mitochondrial proteins.

metal_seq_neibor

The sequence distance between the SAP site and its nearest residue holding the functional site with Feature Key of METAL [18].

MIYS850103

Quasichemical energy of interactions in an average buried environment [32].

modres_seq_neibor

The sequence distance between the SAP site and its nearest residue holding the functional site with Feature Key of MOD_RES [18].