Table 2 Best patterns describing amyloid protein families

Alpha Fibrinogen

A

0.91

C-x(7,8)-C-x(3)-[DGHMNPS]-W-[DGHMNPS]-x-K-C-P

P

0.13

W-W-[LIVMFYW]-x(2)-C-x(2)-[GSA]-x(2)-N-G

Alpha Synuclein

A

1

S-[KR]-T-K-E-G-V-V-H-G

Amyloid Beta Precursor

A

1

S-x(0,3)-N-[KV]-[GP]-A-[IV]-[AI]-[DEG]-[EL]-[IM]-[QV]-[DG]-[EG]-V-[DV]-[EI]-[AL]

P

0.75

G-Y-E-N-P-T-Y-[KR]

Apolipoprotein A-1

A

0.97

V-[HKR]-x-K-x-[DEGHKNPQRSTY]-[ENPQTV]-x-L-[DE]-[DEHNPQSWY]-[FILMVY]-[DEGHKNPQRSTY]-x-[EHIKLMQV]-x(2)-[ENPQTV]-[DEHKNPQY]-[ACHILMV]

Atrial Natriuretic Factor

A*

0.98

C-F-G-x-[KR]-[ILM]-D-R-I-G-[ANST]-x-S-[GS]-[LM]-G-C-[GNS]-[GNPRS]

P

0.53

C-F-G-x(3)-[DEA]-[RH]-I-x(3)-S-x(2)-G-C

Beta-2 Microglobulin

A

0.71

P-x(2,3)-Q-[ETV]-[DGY]-[PST]-[ER]-x-[PW]-x-[DENQS]-x-[DGNT]-[DEKRT]-x-[NT]-x-[AILV]

P

0.23

[FY]-{L}-C-x-[VA]-{LC}-H

C-Protein

A

1

R-L-L-[IV]-[AIV]-[VY]-[KV]-[PV]-[AIV]-[PV]

P⁺

0.95

I-P-C-C-P-V

Calcitonin

A*

1

L-S-T-C-[MV]-L-[GS]-x-[LY]-[STW]

P

0.53

C-[SAGDN]-[STN]-x(0,1)-[SA]-T-C-[VMA]-x(3)-[LYF]-x(3)-[LYF]

Cystatin C

A

0.68

V-x(2,6)-Q-x(1,2)-V-[AS]-G-x(2)-[HY]-[FIKRY]-[FLMV]-x-[IMV]

P

0.29

[GSTEQKRV]-Q-[LIVT]-[VAF]-[SAGQ]-G-{DG}-[LIVMNK]-{TK}-x-[LIVMFY]-x-[LIVMFYA]-[DENQKRHSIV]

Gelsolin

A

1

D-[DS]-[IV]-M-[ILMV]-L-D-[AST]-[GW]-[DN]

Huntingtin

A

0.94

L-Y-[GK]-E-I-K-[KR]-N-[AG]-[AN]

Insulin

A

0.95

L-C-G-x-[DGHMNPS]-L-x(0,1)-V-x(5,6)-C-x(3)-G

P

0.49

C-C-{P}-{P}-x-C-[STDNEKPI]-x(3)-[LIVMFS]-x(3)-C

Islet Amyloid Polypeptide

A

1

S-[HNRS]-N-x(1,2)-G-[APT]-[AIV]-[FL]-x-[PS]-[PT]-[DKNS]

P

0.33

C-[SAGDN]-[STN]-x(0,1)-[SA]-T-C-[VMA]-x(3)-[LYF]-x(3)-[LYF]

Lactadherin

P

0.15

[GASP]-W-x(7,15)-[FYW]-[LIV]-x-[LIVFA]-[GSTDEN]-x(6)-[LIVF]-x(2)-[IV]-x-[LIVT]-[QKMT]-G

Lactoferrin

A

1

P-V-[AT]-E-A-[EKQR]-[NS]-C-[HY]-L-A-x-A-P-[NS]-H-A-V-V-S

P

0.38

[DENQ]-[YF]-x-[LY]-L-C-x-[DN]-x(5,8)-[LIV]-x(4,5)-C-x(2)-A-x(4)-[HQR]-x-[LIVMFYW]-[LIVM]

Lysozyme

A

1

G-[ILV]-[FL]-[EQ]-[IL]-N-[DNS]-x(2)-W

P

0.95

C-x(3)-C-x(2)-[LMF]-x(3)-[DEN]-[LI]-x(5)-C

Prolactin

A

1

R-D-S-x-K-[IV]-[DK]-[NST]-[FY]-L

P

0.44

C-x-[STN]-x(2)-[LIVMFYS]-x-[LIVMSTA]-P-x(5)-[TALIV]-x(7)-[LIVMFY]-x(6)-[LIVMFY]-x(2)-[STACV]-W

Serum amyloid A

A*

0.96

N-x(1,4)-D-x(3)-[HRY]-[AG]-[PR]-G-[GNS]-x-[DEW]-A-[AQ]-[EKQR]

P⁺

0.95

A-R-G-N-Y-[ED]-A-x-[QKR]-R-G-x-G-G-x-W-A

Tau

A*

1

G-S-x(0,1)-D-N-[IMV]-[KNRT]-H-x-P-G-G-G-[EKNS]-[KV]-[KQ]-I-x-[DHTY]

P

0.40

G-S-x(2)-N-x(2)-H-x-[PA]-[AG]-G(2)

Transthyretin

A

1

C-P-L-[MT]-V-K-[IV]-L-D

P⁺

0.56

[KH]-[IV]-L-[DN]-x(3)-G-x-P-[AG]-x(2)-[LIVM]-x-[IV]

Prion Protein (PrP)

A

0.99

A-x(0,1)-A-x(0,1)-G-x(0,1)-A-[AIV]-[AGV]-[GKY]-x-[AILMV]-x-[DGR]-x(2)-[LMR]-[GPS]-[HRS]

P⁺

0.93

E-x-[ED]-x-K-[LIVM](2)-x-[KR]-[LIVM](2)-x-[QE]-M-C-x(2)-Q-Y

Sup35

A

0.97

G-x(0,1)-A-x(1,2)-A-[ADEGKNPQRST]-x-[ADEGKNPQRST]-x-L-V-I-S-[ADEGKNPQRST]-[ADEGKNPQRST]-[ADEGKNPQRST]-G-E-[CFHILMVWY]-E

P

0.13

D-[KRSTGANQFYW]-x(3)-E-[KRAQ]-x-[RKQD]-[GC]-[IVMK]-[ST]-[IV]-x(2)-[GSTACKRNQ]

Ure2

A

0.97

E-F-P-E-V-Y-K-W-T-K