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Table 2 Overlapping EC classes, for those cases where there are more than two errors from a true EC class to an assigned EC class.

From: CORRIE: enzyme sequence annotation with confidence estimates

True EC

Name of true class

Assigned EC

Name of assigned class

Common activity

Difference

2.7.7.7

DNA-directed DNA polymerase

2.7.7.6

DNA-directed RNA polymerase

DNA-dependent nucleotidyltransferase

Substrate: DNA or RNA

1.6.99.5

NADH dehydrogenase (quinone)

1.6.5.3

NADH dehydrogenase (ubiquinone)

NADH dehydrogenase

Electron acceptor: quinone or ubiquinone

3.2.1.91

Cellulose 1,4-beta-cellobiosidase

3.2.1.4

Cellulase

Hydrolysis of 1,4-beta-D-glucosidic linkages

Exo-hydrolysis or endo-hydrolysis

2.7.1.137

Phosphatidylinositol 3-kinase

2.7.11.1

Non-specific Ser/Thr protein kinase

Kinase

Substrate: PI3 or Ser/Thr

2.4.1.242

NDP-glucose – starch glucosyltransferase

2.4.1.21

Starch synthase

Starch glucosyltransferase

Substrate: NDP-glucose or ADP-glucose

3.6.3.15

Sodium-transporting two-sector ATPase

3.6.3.14

H+-transporting two-sector ATPase

Ion transporting two sector ATPase

Ion specificity: NA+ or H+

  1. Column names: True EC/Name – the real EC number/name; Assigned EC/Name – the assigned properties made by CORRIE; Common activity/Difference – similarities and differences of substrate specificity and mechanisms for the corresponding reaction pairs.