From: Evaluation of high-throughput functional categorization of human disease genes
Valle's Category | Original curation HDG count | True Positives | False Negatives | False Positives | GO-clustering precision | GO-clustering recall |
---|---|---|---|---|---|---|
Cell Signaling | 20 | 0 | 20 | 0 | N/A | 0% |
Channel | 32 | 28 | 4 | 7 | 34% | 88% |
Enzyme | 232 | 143 | 89 | 15 | 85% | 61% |
Extracellular matrix component | 54 | 17 | 37 | 21 | 63% | 31% |
Hormone | 14 | 0 | 14 | 0 | N/A | 0% |
Immunoglobulin | 4 | 0 | 4 | 0 | N/A | 0% |
Intracellular matrix component | 50 | 42 | 8 | 10 | 43% | 84% |
Modulator of protein function | 105 | 28 | 77 | 231 | 25% | 27% |
Receptor | 86 | 58 | 28 | 10 | 73% | 67% |
Transcription factor | 79 | 68 | 11 | 4 | 73% | 86% |
Transmembrane Transporter | 35 | 15 | 20 | 42 | 32% | 43% |
Totals & overall accuracy scores | 711 | 399 | 312 | 340 | 62%** | 56%** |