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Table 3 Distribution of functional classes and temporal gene expression clusters between predicted NF-κB target and non-target genes in INS-1 cells.

From: In silico identification of NF-kappaB-regulated genes in pancreatic beta-cells

Temporal cluster

P-value

cluster 1

0.006

cluster 2

1

cluster 3

0.66

cluster 4

1

cluster 5

0.36

cluster 6

0.32

cluster 7

0.87

cluster 8

0.73

cluster 9

1

cluster 10

0.14

cluster 11

0.64

cluster 12

0.66

cluster 13

0.87

cluster 14

0.53

cluster 15

1

Functional class

P-value

Metabolism

0.65

Protein synthesis

0.87

Ionic channels

0.48

Hormones and growth factors

1

Cytokines, chemokines

0.05

Signal transduction

0.94

MHC related

0.06

Cell adhesion

0.03

Transcription factors

0.45

RNA synthesis

1

Cell cycle

1

Defense repair

0.79

Apoptosis ER stress

1

Miscellaneous

0.81

  1. The classifications involved 225 NO-independent and cytokine-regulated genes in INS-1E cells [6]. 32 of them were predicted as NF-κB targets by the present approach. P-value: statistical significance of the overlap between the genes belonging to the functional or temporal class and the set of predicted NF-κB target genes (hypergeometric probability distribution).