In silico identification of NF-kappaB-regulated genes in pancreatic beta-cells

BMC Bioinformatics

Table 2 Comparison of predicted NF-κB-regulated genes in different species

Species 1	Species 2	Targets in 1	Targets in 2	Overlap	Total # of genes	P-value
Rat	mouse	217	230	82	2688	3.7e-37
Rat	chimpanzee	205	281	63	2540	6.2e-16
Rat	human	218	310	64	2666	6.9e-14
Human	rat	504	296	66	7545	3.7e-19
Human	mouse	541	355	81	7915	2.1e-23
Human	chimpanzee	536	470	353	8196	<1e-300

Targets in 1: number of NF-κB targets in species 1; Targets in 2: number of NF-κB targets in species 2; Overlap: number of NF-κB targets in common between species 1 and 2; Total # of genes: number of analyzed pairs of homologous genes; P-value: probability to observe at least the obtained common number of NF-κB targets (calculated on the basis of the hypergeometric distribution).

ISSN: 1471-2105