Investigations into the relationship between feedback loops and functional importance of a signal transduction network based on Boolean network modeling

Table 1 Classification of proteins and their functional importance in the hippocampal CA1 neuronal signal transduction network

The functional importance with respect to mutant phenotypes
	No feedback loop			Feedback loop			Total
	N	U	R	N	U	R	N	U	R
Low connectivity	49	142	34.5%	9	24	37.5%	58	166	34.9
High connectivity	19	55	34.5%	60	118	50.8%	79	173	45.7%
Total	68	197	34.5%	69	142	48.6%	137	339	40.4%
The functional importance with respect to evolutionary rates
	No feedback loop			Feedback loop			Total
	N	U	R	N	U	R	N	U	R
Low connectivity	36	208	17.3%	6	40	15.0%	42	248	16.9%
High connectivity	10	71	14.1%	37	136	27.2%	47	207	22.7%
Total	46	279	16.5%	43	176	24.4%	89	455	19.6%

U : The number of proteins belonging to the corresponding class.
N : The number of important proteins with either a "Lethal" phenotype or a "Slow" evolutionary rate.
R : N/U × 100(%).

ISSN: 1471-2105