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Table 1 Classification of proteins and their functional importance in the hippocampal CA1 neuronal signal transduction network

From: Investigations into the relationship between feedback loops and functional importance of a signal transduction network based on Boolean network modeling

The functional importance with respect to mutant phenotypes
  No feedback loop Feedback loop Total
  N U R N U R N U R
Low connectivity 49 142 34.5% 9 24 37.5% 58 166 34.9
High connectivity 19 55 34.5% 60 118 50.8% 79 173 45.7%
Total 68 197 34.5% 69 142 48.6% 137 339 40.4%
The functional importance with respect to evolutionary rates
  No feedback loop Feedback loop Total
  N U R N U R N U R
Low connectivity 36 208 17.3% 6 40 15.0% 42 248 16.9%
High connectivity 10 71 14.1% 37 136 27.2% 47 207 22.7%
Total 46 279 16.5% 43 176 24.4% 89 455 19.6%
  1. U : The number of proteins belonging to the corresponding class.
  2. N : The number of important proteins with either a "Lethal" phenotype or a "Slow" evolutionary rate.
  3. R : N/U × 100(%).