Skip to main content
Figure 2 | BMC Bioinformatics

Figure 2

From: Investigations into the relationship between feedback loops and functional importance of a signal transduction network based on Boolean network modeling

Figure 2

Correlation of connectivity and the NuFBL to the functional importance in Boolean networks. (a) Correlation between connectivity and the functional importance of network nodes with respect to initial state mutations. (b) Correlation between the NuFBL and the functional importance of network nodes with respect to initial state mutations. (c) Correlation between connectivity and the functional importance of network nodes with respect to update rule mutations. (d) Correlation between the NuFBL and the functional importance of network nodes with respect to update rule mutations. In each figure, all nodes were classified into five groups according to their connectivity or NuFBL ranks. All the results represent the average over randomly generated 2000 Boolean networks with |V| = 14 and |A| = 19. For each group, the average and the confidence interval for 95% confidence level of the functional importance are shown on the y-axis. Here, the functional importance of a network node is defined by the probability with which the network converges to a different attractor when the value of the node is mutated. For other Boolean networks with different |V| and |A|, we also obtained similar results (see additional data file 1).

Back to article page