Figure 1From: MiRFinder: an improved approach and software implementation for genome-wide fast microRNA precursor scansMutation profile of miRNA. There are three types of mutations that cause slight disturbance of the secondary structure of pre-miRNA: (1) mutations in the loop region; (2) mutations between A and G, U and C in the stem region; (3) mutations in the interrelated region of both arms that do not break the base-pairing. The three types of mutations are marked by the numbers 1, 2 and 3, respectively, under the alignments. The conserved nucleotides are marked as "*".Back to article page