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Table 1 Accuracy of ASMPKS in the domain identification

From: ASMPKS: an analysis system for modular polyketide synthases

 

No of total

No of predicted

No of correct

SP(%)

SN(%)

Group 1

906

900

899

99.8

99.2

Group 2

792

779

777

99.7

98.1

Group 3

129

111

110

99.1

85.2

  1. Specificity (SP) = Correct predictions/Total predictions,
  2. Sensitivity (SN) = Correct predictions/Total domains
  3. The group 1 is composed of 906 domains of 20 polyketides, amphotericin, ascomycin, avermectin, epothilone, erythromycin, megalomicin, myxalamid, myxothiazol, niddamycin, nystatin, oleandomycin, pikromycin, pimaricin, pyoluteorin, rapamycin, rifamycin, soraphen, spinosad, stigmatellin, and tylactone, that are included in PKSDB.
  4. The group 2 is composed of 792 domains in modular PKSs of 17 type I polyketides which are aureothin, borrelidin, bryostatin, concanamycin a, coronatine, fk506, fr-008, geldanamycin, herbimyycin a, lankamycin, methymycin, monensin, mycolactone, nanchangmycin, phoslactomycin, rubradirin and vicenistatin.
  5. The group 3 is composed of 129 domains of 5 PKS-NRPS hybrid types which are bacillaene, cryptophycin, lankacidin, leinamycin and pederin.