Figure 6From: Optimization of filtering criterion for SEQUEST database searching to improve proteome coverage in shotgun proteomicsFlowchart of the optimization procedure using genetic algorithm. It starts with the initialization phase, which randomly generates the initial population P0. Population in the next generation Pi+1 is obtained by applying genetic operators on current population Pi. Fitness for each individual (criterion) is evaluated as the number of filtered peptides. Evolution continues until a terminating condition is reached. The selection, mutation and cross-over operator are used in genetic algorithm.Back to article page